Results/Conclusions Specifically, results indicate that landscape fragmentation in urban fringes and urbanizing frontiers is generally higher than that in the central and rural areas and it commonly takes on an inverted “U” shape along urban-to-rural gradient. In addition, the relation between landscape fragmentation and degree of urbanization can be represented as a multinomial curve with an inverted “U” shape that exhibits a threshold of the changes of landscape fragmentation as the degree of urbanization reaches between 42%—45%; and this relationship, in essence, reflected the urban growth theory and dynamics of landscape fragmentation in response to urbanization: that is, the urbanization process has brought about enormous intensification of landscape fragmentation in the initial stages of urbanization whereas dramatically decreased its degree when urban built-up areas become dominant. Further investigation on the uneven spatial distribution of landscape fragmentation revealed the social and economic driving forces that contribute to influence landscape fragmentation and transform landscape compositions. Besides, this study applied correlation and regression analysis to explore the linkages between social and economic variables and urban landscape fragmentation and landscape patterns, which have important implications for effective spatial planning and sustainable landscape management in urban regions.