As we progress into the Anthropocene Epoch, agricultural systems, being involved in the most active human activities, are confronted with serious, complex, and even unprecedented environmental challenges due to multiple global changes in climate, air pollution, land use change and management etc. Those changing multiple drivers derived from direct and indirect human activities occur across temporal and spatial scales, and interactively work together to make tremendous impacts on agroecosystems from cellular chemistry to ecosystem processes. For example, climate change, one long-term control factor, dominantly influences agroecosystem processes simultaneously working with short-term controls (such as disturbance regime, human activity, air pollution) characterized by regions and times. Multiple drivers of change form into novel conditions and ultimately cause major changes in the structure and functioning of agroecosystems through altering hydrological and nutrient cycles, influencing soil microbial activity, adding or moving species and so on. To achieve the goals of sustainable agriculture and food systems globally and regionally in coping with the environmental challenges timely, it is urgently needed to understand the dynamic responses of the functions and structures in agroecosystems to the novel conditions i.e. multiple global environment changes across the world. This session aims to convene an array of scholars working up-to-the-minute to show advances in studying responses (ecosystem production, biogeochemical cycles, microbial activity etc.) of diverse agroecosystems (crops, pasture and plantation/managed forest) to multiple drivers of change using different approaches covering field experiments, remote sensing/GIS, modeling, and data synthesis. The primary objectives will be tripled: (1) to present the frontier research progress that have explored the complexity of the interactive effects of multiple drivers or controls and their impacts on agroecosystems; (2) to discuss potential benefits and problems of multiple global change drivers facing divers agroecosystems (crops, pasture and plantation/managed forest) at reginal scales in next decade; (3) to promote the substantial advances in interdisciplinary studies on this challenging issue in future.